Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging inEscherichia coli
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منابع مشابه
Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli.
The SsrA or tmRNA quality control system intervenes when ribosomes stall on mRNAs and directs the addition of a C-terminal peptide tag that targets the modified polypeptide for degradation. Although hundreds of SsrA-tagged proteins can be detected in cells when degradation is prevented, most of these species have not been identified. Consequently, the mRNA sequence determinants that cause ribos...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.052707199